Sybille Facca
University of Strasbourg , France
Title: Development of nanostructured biomaterials for bone and osteo-articular regeneration
Biography
Biography: Sybille Facca
Abstract
During the last ten years, tissue engineering has merged with regenerative nanomedicine by combination, not only of new biomaterials but also of stem cell technology and growth factors. The goal of this work was to use bone and cartilage engineering as a model, in order to improve and to develop active and living nanostructured implants. We were interested in the development of biomaterials (natural or synthetic), tridimensional (3D), transplantable for bone and cartilage diseases treatments, that are able to induce more cellular differentiation and improved tissue regeneration. We have developed 3 types of nanostructured implants, (i) titanium implants coated with hydroxyapatite and carbon nanotubes in order to improve osteoformation and osteoinduction around arthroplasty implants; (ii) active capsules functionalized by growth factors and stems cells for bone induction (in vitro/in vivo) after a bone defect; (iii) electrospun nanofibrous membranes functionalized by growth factors and (Osteoblasts/Chondrocytes) for bone and cartilage regeneration, in vitro and in vivo.
Recent Publications:
1. Facca S, Lahiri D, Fioretti F, Messadeq N, Mainard D, Benkirane-Jessel N, Agarwal A (2011) In vivo osseointegration of nano-designed composite coatings on titanium implants. ACS Nano 5:4790-4799.
2. Facca S, Lahiri D (2012) Nanoreinforcement of hydroxyapatite coatings on titanium for osseointegration of orthopaedic implants. Comput Methods Biomech Biomed Engin. 15 Suppl 1:10-11.
3. Eap S, Keller L, Ferrand A, Schiavi J, Lahiri D, Lemoine S, Facca S, Fioretti F, Mainard D, Agrawal A, Benkirane-Jessel N (2014) Nanomechanical properties of active nanofibrous implants after in vivo bone regeneration. Nano Life 04(01) DOI: 10.1142/S1793984414500019.
4. Vaiss L, Ichihara S, Ramirez DG, Hendriks S, Liverneaux P, Facca S (2015) A comparative study about ionizing radiation emitted during radiological "skyline" view of the wrist in pronation versus supination. Eur J Orthop Surg Traumatol 25:309-311.
5. Perruisseau-Carrier A, Bahlouli N, Po C, P Vernet, Facca S , Liverneaux P (2017) Analysis of the modifications of MRI signal of the brachial plexus of rats: Comparative study before and after freezing/thawing. Ann Chir Plast Esthet pii: S0294-1260 (16) 30214-X.