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Thierry Delair

Thierry Delair

University of Lyon, France

Title: Polyelectrolyte nano-complexes-Safe and Efficient tools for the delivery of drugs or vaccine

Biography

Biography: Thierry Delair

Abstract

The complexation of polyelectrolytes is very attractive to process polysaccharides into biomaterials, because it is energy efficient, requires no toxic chemical, has a low environmental impact and can be applied to biocompatible polymers such as polysaccharides.We used chitosan, a copolymer of N-acetyl glucosamine and glucosamine obtained from the partial deacetylation of chitin as polycation and a variety of polyanions such as dextran sulphate, hyaluronan, heparin, and chondroitin sulphate. These polysaccharides are generally regarded as safe and some of them can be found in the extracellular matrix of mammals. In this contribution we will present our latest achievement in the control of the elaboration, structure and performances of polyelectrolyte nanocomplexes as drug and vaccine carriers of high potential. In particular, we will address the issues of colloidal stability in physiological media, a major limiting factor in the development of this technology; the nanocomplex loading with drugs or vaccine; the targeting of these nanodelivery systems. The formation of polyelectrolyte complexes is spontaneous at room temperature, i.e. under kinetics control. We will present an alternative approach close to the thermodynamic equilibrium and discuss the potentiality of this particularly innovative synthesis route. Finally, we will present our latest results on the delivery of anti-retroviral drug and the inhibition of the infection by the HIV-1 virus of hPBMCs in vitro.
 
 
 

Recent Publications:
 

1. Wu, D., Delair, T. (2015) Stabilization of chitosan/hyaluronan colloidal polyelectrolyte complexes in physiological conditions, Carbohydrate Polymers 119, 149-158.
2.  Costalat, M., Alcouffe, P., David, L., and Delair, T. (2015) Macro-hydrogels versus nanoparticles by the controlled assembly of polysaccharides, Carbohydrate Polymers 134, 541-546.
3. Costalat, M., David, L., and Delair, T. (2014) Reversible controlled assembly of chitosan and dextran sulfate: A new method for nanoparticle elaboration, Carbohydrate Polymers 102, 717-726.
4.  Polexe, R. C., Terrat, C., Verrier, B., Cuvillier, A., Champier, G., and Delair, T. (2013) Elaboration of targeted nanodelivery systems based on colloidal polyelectrolyte complexes (PEC) of chitosan (CH)-dextran sulphate (DS), European Journal of Nanomedicine 5.
5. Delair, T. (2011) Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules, European Journal of Pharmaceutics and Biopharmaceutics 78, 10-18.